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Actually it is not weak if given in adequate doses. A dose of *2 to 4 mg is the equivalent of .6 to 1.25 mg of conjugated estrogen or estrone and is just as effective. It has been available in Europe for many years. Importantly, estriol does not lose its unique identity, as does estradiol. It remains estriol. Lemon, reporting on chemically induced rat mammary carcinoma, demonstrated a notable inhibition of mammary carcinogens with estriol therapy compared with therapy using estrone and estradiol. According to an unpublished study by Henry M. Lemon, John F. Foley, and M. Anne Kessinger, 2.5 to 5 mg of estriol, equivalent to a little more than .65 and 1.25 mg of conjugated estrogens were used, with the informed consent of patients, in postmenopausal women with breast carcinoma and metastases. The preliminary investigation was initiated as a trial of the safety and estrogenicity of the hormone in postmenopausal women with breast cancer and not primarily to test its activity as an alternative therapeutic estrogen for breast cancer. Thirty-seven percent receiving this small dosage had remission or arrest of metastatic lesions.
Following excerpts are from Health and Healing by Dr. Julian Whitaker M.D.
Estroil's anti-cancer effect is thought to be due to its anti-estrone characteristics. It apparently blocks the stimulatory effect of estrone on the breast. Estriol is weaker in that it requires *2 to 4 mg of estriol to equal the effects of .6 to 1.25 mg of Premarin. But that is inconsequential when one considers that the more estriol a woman takes, the less likely she gets breast cancer, which is exactly the opposite of the dosage relationships of commonly used estrogens.
Following excerpts are from "What Your Doctor May Not Tell You About Menopause" by Dr. John R. Lee, M.D.
If a three-month trial of progesterone plus proper diet and supplements of magnesium and B6 do not relieve hot flashes or vaginal dryness, then low-dose natural estrogen may be helpful. All the available evidence we have so far indicates that estriol is the safest estrogen to use to control menopausal symptoms, and that it may even be protective against cancer. If you need to supplement some estrogen, you can use a natural estrogen in a cream. 1 to 4 mg daily for estriol. We can't emphasize strongly enough that no women, with or without a uterus or ovaries, should ever take estrogen alone. It should always be *combined with natural progesterone.
Multiple Sclerosis and Estriol
It has been known for years that pregnant women with Multiple Sclerosis get better in the last trimester of their pregnancy. In the third trimester, the hormone estriol is at high levels. Multiple Sclerosis strikes when white blood cells escape from blood vessels in the brain and attack nerves. Doctors say estriol helps stop those cells from escaping. Dr. Voskuhl M.D., says, "If you ask them, they will tell you that they get better during pregnancy. The MS does better." Dr. Rhonda Voskuhl, a neurologist at UCLA Medical Center, has used the information that she has from many female MS patients to initiate a study on the effects of estriol on Multiple Sclerosis. First, Dr. Voskuhl gave estriol to mice with MS. They regained strength in their legs and appeared to feel much better. Next several studies using estriol with female MS patients showed very promising results. Doctors stress that estriol is not a cure, but just another little piece of the jigsaw puzzle that might arrest the progress of the disease.
*In the quote "2-4 mg" of estriol, they are speaking of oral use not topical.
*Combined means use natural progesterone crème in the same month that natural estriol crème is used.
All information compiled is strictly for educational purposes and BioCentric Laboratories Inc. is not responsible for the information. It is recommended to consult with a health professional. For more information read material by Dr. John Lee M.D., Dr. Christiane Northrup M.D. and Dr. Julian Whitaker M.D.
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